Background: Even though low back pain (LBP) is common, some occupations pose a higher risk. Identifying these occupations and specific factors will help to reduce the suffering and burden. This study aims to compare the prevalence of chronic LBP among bus drivers and to find its association with some occupational factors. Materials and Methods: It is a cross-sectional study to compare prevalence of LBP and factors associated with it, in two groups of drivers (n = 178) and nondrivers (n = 184). Results: The 10 years’ percentage prevalence of LBP was found to be 70.8 and 51.6 among drivers and nondrivers respectively, whereas point prevalence in the same was 64.0 and 44.6. Drivers are at a higher risk for LBP with Odds ratio-2.270 (1.471-3.502). Risk factors such as prolonged sitting in one posture, night shifts, job dissatisfaction, tobacco use, and lack of exercise were significantly higher among drivers. Though the prevalence and intensity of LBP was higher among drivers, their number of leaves and hospital admitted days were less among drivers. Conclusion: This is a potential group for intervention as prevalence of LBP, neck pain, and most of the suspected risk factors were higher among the drivers. Drivers got less recovery time and had higher sequelae.